Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP
نویسندگان
چکیده
منابع مشابه
Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse
Mutations, duplication and triplication of α-synuclein genes are linked to familial Parkinson's disease (PD), and aggregation of α-synuclein (α-syn) in Lewy bodies (LB) is involved in the pathogenesis of the disease. The targeted overexpression of α-syn in the substantia nigra (SN) mediated by viral vectors may provide a better alternative to recapitulate the neurodegenerative features of PD. T...
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1 Department of Archaeology and Anthropology, Bristol University, Bristol, UK 2 Department of Geography, Durham University, Durham, UK 3 Institute of Hazard , Risk and Resilience, Durham University, Durham, UK 4 School of Biological and Biomedical Sciences, Durham University, Durham, UK 5 Department of Mathematical Sciences, Durham University, Durham, UK 6 Durham University Business School, Dur...
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2017
ISSN: 0165-6147
DOI: 10.1016/j.tips.2017.03.010